RESEARCH ARTICLE


Polysorbate 80 Coated Solid Lipid Nanoparticles for the Delivery of Temozolomide Into the Brain



Pawan Yadav1, Goutam Rath1, Gazal Sharma1, Ranjit Singh2, Amit Kumar Goyal1, *
1 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
2 Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Sahranpur-247341 UP, India


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© 2018 Yadav et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Mobile: 9888206383; E-mails: amitkumargoyal1979@gmail.com; goyalddrl@gmail.com


Abstract

Introduction:

Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.

Methodology:

To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.

Results:

Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.

Conclusion:

The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.

Keywords: Brain targeting, Blood-brain barrier, Temozolomide, Solid lipid nanoparticles, Glioblastoma multiform, Polysorbate 80.