RESEARCH ARTICLE
The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics
Karl K. Rozman*
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66212, USA.
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 87
Last Page: 88
Publisher Id: TOPHARMJ-2-87
DOI: 10.2174/1874143600802010087
Article History:
Received Date: 2/4/2008Revision Received Date: 5/8/2008
Acceptance Date: 8/8/2008
Electronic publication date: 22/8/2008
Collection year: 2008
© 2008 Karl K. Rozman et al.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The relationship dose x time = constant [mg · hr] has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experiment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.
Keywords: Dose, time, toxicology/pharmacology.
