RESEARCH ARTICLE


Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in Rats



Geeta Deswal1, *, Kumar Guarve1, Priyanka Kriplani1, Ashwani K. Dhingra1, Bhawna Chopra1, Jaspreet Sidana2
1 Guru Gobind Singh College of Pharmacy, City Center Road, Yamuna Nagar-135001, Haryana, India
2 M.M. College of Pharmacy, MMU, Mullana, Ambala, Haryana, India

Article Information


Identifiers and Pagination:

Year: 2019
Volume: 9
First Page: 5
Last Page: 11
Publisher Id: TOPHARMJ-9-5
DOI: 10.2174/1874143601909010005

Article History:

Received Date: 30/5/2019
Revision Received Date: 24/9/2019
Acceptance Date: 10/10/2019
Electronic publication date: 15/11/2019
Collection year: 2019

© 2019 Deswal et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Guru Gobind Singh College of Pharmacy, City Center Road, Yamuna Nagar-135001, Haryana, India; Tel: 9991414069; Email:deswalgeeta@gmail.com


Abstract

Background:

Literature reports numerous causes for liver damage, which mainly include viral hepatitis (most commonly hepatitis B), cirrhosis, cell stress, hepatic damage by NSAIDs or alcohol. In the present study, methanolic extracts of Tectona grandis leaves were evaluated for hepatoprotective activity against CCl4 induced liver damage in rats.

Methods:

Hepatic injury in rats was carried out using the CCl4-induced hepatotoxic model. Methanolic extracts of Tectona grandis were administered orally at two different doses (200mg/kg & 400mg/kg) daily. The biochemical parameters (SGOT, SGPT, ALP, and serum bilirubin) were estimated using Reitman and Frankel's method in addition Kind King’s method.

Results:

The preliminary phytochemical studies confirmed the existence of saponins, carbohydrates, tannins, and flavonoids. CCl4 treated group boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant (200 mg/kg & 400 mg/kg) and standard drug silymarin (100 mg/kg) produced a significant decrease in raised levels of these enzymes as compared to control.

Conclusion:

The results clearly indicate that Tectona grandis leaves have notable hepatoprotective activity in rats hepatic damage induced by CCl4.

Keywords: Tectona grandis, Hepatoprotective, Histopathology, CCl4, SGOT, SGPT.