RESEARCH ARTICLE


Primary Sclerosing Cholangitis - Current Issues in Clinical Practice



L. Corless1, 2, H. Tsai*, 1
1 Department of Gastroenterology, Castle Hill Hospital, Cottingham, UK
2 Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK


© 2012 Corless and Tsai;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Gastroenterology, Castle Hill Hospital Cottingham UK; Tel: 7880508381; Fax: 1482622207; E-mail: hhtsai @ doctors.org.uk


Abstract

Aims:

To review current issues in the diagnosis and treatment of primary sclerosing cholangitis.

Methods:

search of PubMed using the terms “primary sclerosing cholangitis”, “PSC”, “cholangitis” and “cholestasis”, as well as by review of current guidelines from the major international liver societies.

Results:

Primary sclerosing cholangitis is still a challenging condition to diagnose and manage, but newer imaging modalities like MRCP and timing of liver transplantation point the way forward.

Keywords: Primary sclerosing cholangitis, ulcerative colitis.