Primary Sclerosing Cholangitis - Current Issues in Clinical Practice

L. Corless1, 2, H. Tsai*, 1
1 Department of Gastroenterology, Castle Hill Hospital, Cottingham, UK
2 Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK

© 2012 Corless and Tsai;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Gastroenterology, Castle Hill Hospital Cottingham UK; Tel: 7880508381; Fax: 1482622207; E-mail: hhtsai @



To review current issues in the diagnosis and treatment of primary sclerosing cholangitis.


search of PubMed using the terms “primary sclerosing cholangitis”, “PSC”, “cholangitis” and “cholestasis”, as well as by review of current guidelines from the major international liver societies.


Primary sclerosing cholangitis is still a challenging condition to diagnose and manage, but newer imaging modalities like MRCP and timing of liver transplantation point the way forward.

Keywords: Primary sclerosing cholangitis, ulcerative colitis.