RESEARCH ARTICLE


Attenuation of Drug-Induced Loss of Righting Reflex Response by Pretreatment with a Nitric Oxide Donor



Yuhua (Al) Wang1, Raymond M. Quock2, Robert D. Keegan*, 3
1 Graduate Program in Pharmacology/Toxicology and
2 Graduate Program in Pharmacology/Toxicology and Department of Pharmaceutical Sciences, College of Pharmacy and
3 Graduate Program in Pharmacology/Toxicology and Department of Pharmaceutical Sciences, College of Pharmacy and Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA


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© 2011 Wang et al;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, P.O. Box 646610, Pullman, WA 99164-6610, USA; Tel: +15093350770; Fax: +15093350880; E-mail: rdk@vetmed.wsu.edu


Abstract

Keywords: Nitric oxide, loss of righting reflex, chloral hydrate, sodium barbital, midazolam, ketamine/xylazine, mice.