RESEARCH ARTICLE


Stress-Induced Hyperthermia in Translational Stress Research



Christiaan H. Vinkers*, 1, Renske Penning1, Marieke M. Ebbens1, Juliane Hellhammer2, Joris C. Verste1, Cor J. Kalkman3, Berend Olivier1, 4
1 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS) and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
2 Daacro Clinical Research Organization, Trier, Germany
3 Department of Anesthesiology, University Medical Centre Utrecht, Utrecht, The Netherlands
4 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

Article Information


Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 30
Last Page: 35
Publisher Id: TOPHARMJ-3-30
DOI: 10.2174/1874143601004010030

Article History:

Received Date: 20/10/2009
Revision Received Date: 13/4/2010
Acceptance Date: 20/4/2010
Electronic publication date: 2/6/2010
Collection year: 2010

© 2010 Vinkers et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the the Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands; Tel: +31(0)302531599; Fax: +31(0)302537900; E-mail: c.h.vinkers@uu.nl


Abstract

The stress-induced hyperthermia (SIH) response is the transient change in body temperature in response to acute stress. This body temperature response is part of the autonomic stress response which also results in tachycardia and an increased blood pressure. So far, a SIH response has been found in a variety of species (including rodents, baboons, turtles, pigs, impalas and chimpanzees), and there are indications that stress exposure alters body temperature in humans. This review aims to assess the translational potential and the different aspects of the body temperature reaction in response to stress. If stress-induced temperature changes are consistent across species, the SIH paradigm may be employed in preclinical and clinical setups and provide a tool to examine the pharmacological, genetic and mechanistic background of stress at both the preclinical and the clinical level.

Keywords: Translational, autonomic nervous system, stress, anxiety model, emotional fever, menopausal hot flush.