Potential Benefits of Peroxynitrite
Bobby D. Nossaman 1, 2, Philip J. Kadowitz 2, *
Identifiers and Pagination:Year: 2008
First Page: 31
Last Page: 53
Publisher Id: TOPHARMJ-2-31
Article History:Received Date: 4/3/2008
Revision Received Date: 24/3/2008
Acceptance Date: 29/4/2008
Electronic publication date: 3/6/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of platelet aggregation, inhibition of inflammatory cell adhesion, and protection against ischemia/reperfusion injury in the heart. It is our hypothesis that PN may serve to inactivate superoxide and prolong the actions of NO in the circulation. This manuscript reviews the beneficial effects of PN in the cardiovascular system.