RESEARCH ARTICLE


Characterization of Single Nucleotide Polymorphisms in 13 Members of the ABC Drug Transporter Genes in Three Different Populations



Zihua Wang1, 2, Samuel S. Chong5, Caroline G.L. Lee1, 3, 4, *
1 Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
2 Graduate Programme in Bioengineering, National University of Singapore, Singapore
3 Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Center, Singapore
4 DUKE-NUS Graduate Medical School, Singapore
5 Departments of Pediatrics and Obstetrics/Gynecology, National University of Singapore, Singapore

Article Information


Identifiers and Pagination:

Year: 2007
Volume: 1
First Page: 1
Last Page: 12
Publisher Id: TOPHARMJ-1-1
DOI: 10.2174/1874143600701010001

Article History:

Received Date: 30/7/2007
Revision Received Date: 06/09/2007
Acceptance Date: 10/09/2007
Electronic publication date: 27/09/2007
Collection year: 2007

© 2007 Wang et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; Tel: 65-6436-8353; Fax: 65-6779-1453; E-mail: bchleec@nus.edu.sg


Abstract

To evaluate the usefulness of the two public databases, HapMap and Perlegen, in facilitating studies associating polymorphisms in these genes with drug response, we examined 111 single-nucleotide-polymorphisms from 13 ABCtransporter genes in Singaporean-Chinese, European-Americans and African-Americans. We found that genotype data from the HapMap/Perlegen databases are generally transferable to different sampling of the same population and to similar populations residing elsewhere. However, not all ABC-transporter family genes are amenable to SNP-tagging due to the low tagging-efficiency of low-LD genes resulting in negligible cost-savings. Hence, alternative approaches may have to be explored for low-LD ABC genes.

Keywords: SNP, haplotype, LD.